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In the human brain, in situ hybridization histochemistry revealed specific labeling for GLP-1 receptor mRNA in several brain areas like the cerebral cortex (especially in the occipital and frontal cortex), hypothalamus (mainly the ventromedial and arcuate nuclei), hippocampus, thalamus, caudate-putamen, and globus pallidum [89]
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Nearly 45% of participants on the drug achieved weight reduction of 30% or more, a threshold Lilly described in a statement as an “incredible number.” The company also noted that a lower dose included in the study was associated with fewer discontinuations due to gastrointestinal side effects such as nausea and diarrhea
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